Monday, August 13, 2007
Medical → Brown Recluse spider bite
The brown recluse spider is native to the United States from the southern Midwest south to the Gulf of Mexico.
Actual brown recluse bites are rare. A minority of bites form a necrotizing ulcer that destroys soft tissue and may take months and possibly (very rarely) years to heal, leaving deep scars.
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| Systemic symptoms (systemic loxoscelism) are observed in fewer than 1% of brown recluse bites and are mostly seen in children, elderly individuals, and immunocompromised patients. Systemic symptoms include fever, chills, nausea, vomiting, anorexia, malaise, arthralgia, myalgia, cellulitis, and a morbilliform rash. Brown recluse spider venom contains sphingomyelinase D, which converts erythrocytic membrane sphingomyelin to ceramide-1-phosphate, leading to hemolysis; platelet aggregation, and thrombosis. Damage to myelin may cause pain and interruption of nerve conduction. Although rare, pulmonary edema may occur as a result of sphingomyelinase D activity in the lungs; acute renal failure has also been reported. Even though systemic loxoscelism is not common, it is important for those suspecting a brown recluse bite to seek medical assistance, as necrosis and systemic loxoscelism can be severe. |
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